The company submitted data to the FDA from five clinical trials, which revealed moderate improvement in fine wrinkling in only 29 of 279 participants who applied tretinoin and sunscreen (compared with 3% in the control group, which used comprehensive sun protection only). Of those that used sun protection and tretinoin, 76% saw minimal improvement, no change or even worsened (compared to 88% of the control group). All individuals within these five clinical trials had lighter skin types (Fitzpatrick Skin Types I – III.) A single study of 107 darkly pigmented subjects (Fitzpatrick Skin Types IV-VI) performed even worse. Of subjects who only used comprehensive sun protection, 49% demonstrated minimal or mild improvement in fine facial wrinkling. When compared to subjects who applied tretinoin and sunscreen only 29% showed improvement;
“This is the most hydrating and potent wrinkle cream that is an absolute must-do with your nightly anti-aging regimen,” said Karuna Chani, a New York-based makeup artist whose high-profile clients include Caroline Scheufele, co-president of Chopard. “It’s incredibly effective because it's scientifically formulated with an amino-peptide complex that promotes cell turnover, skin elasticity and healing. After 15 years of working with all skin types, I can’t stress enough the importance of a good moisturizer to help keep the skin youthful and reduce the appearance of fine lines and wrinkles.”
Like creams, serums can be easy to use and highly effective, depending on the formula. Some serums use botanical antioxidants to treat under eye bags. The antioxidants help to prevent collagen damage, maintain the skin’s elasticity and brighten skin pigmentation. Others contain hyaluronic acid or retinol. Retinol, while highly useful for fighting wrinkles and producing collagen, can be harsh on the sensitive eye area, so always test it first. No matter which serum you pick, try to choose one in a rollerball tube for an easy application that also helps disperse fluid build-up.
We began our search for the best wrinkle cream by pulling top-sellers from major retailers like Walgreens, Amazon, and Target, compiling a list of 112 creams, gels, and serums — everything from high end brands like Estee Lauder and Lancome to drugstore staples like Neutrogena and L’Oreal. From here, we reached out to cosmetic chemists and dermatologists: We wanted to find out which ingredients would help skin look youthful, and which weren’t worth the hype.