The company submitted data to the FDA from five clinical trials, which revealed moderate improvement in fine wrinkling in only 29 of 279 participants who applied tretinoin and sunscreen (compared with 3% in the control group, which used comprehensive sun protection only). Of those that used sun protection and tretinoin, 76% saw minimal improvement, no change or even worsened (compared to 88% of the control group).  All individuals within these five clinical trials had lighter skin types (Fitzpatrick Skin Types I – III.) A single study of 107 darkly pigmented subjects (Fitzpatrick Skin Types IV-VI) performed even worse. Of subjects who only used comprehensive sun protection, 49% demonstrated minimal or mild improvement in fine facial wrinkling. When compared to subjects who applied tretinoin and sunscreen only 29% showed improvement;
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